In Rosen et al. 2022 (n = 253, 5 specialized centers), mid-weight macroporous monofilament polypropylene mesh placed in the retromuscular space with complete fascial closure had lower 2-year recurrence than porcine dermal biologic mesh (5.6% vs. 20.5%; ARR −14.9%, 95% CI −23.8% to −6.1%; p = 0.001) with similar 2-year SSOs requiring intervention (OR 1.22, 95% CI 0.60–2.44; p = 0.58). TAR is added selectively when retrorectus dissection alone cannot achieve low-tension fascial closure (guided by Carbonell rectus-to-defect ratio <2.0 and loss of domain >15%–20%, rather than any rigid width cutoff). Do not extrapolate the Rosen trial to dirty/infected fields (CDC Class IV), uncontrolled intra-abdominal sepsis, bridged defects without fascial closure, intraperitoneal mesh placement, or microporous/multifilament synthetic meshes; conversely, do not state that biologic or biosynthetic meshes are universally contraindicated across all clinical scenarios (§4.0 Guardrail 2). Preoperative Botulinum Toxin A is a selective, institution-specific off-label adjunct for selected complex reconstructions with loss of domain, not a routine requirement: commercial formulations (OnabotulinumtoxinA [Botox], AbobotulinumtoxinA [Dysport], IncobotulinumtoxinA [Xeomin]) are NOT unit-interchangeable, and neuromuscular junction disorders (e.g., myasthenia gravis, Lambert-Eaton syndrome) are contraindications (§4.0 Guardrail 3).