Source · Incarceration · Respiratory complications · Recurrence · Design · n
Hashmi et al., *World J Surg*, 2025 (full text) · Early repair protective: OR 0.43 (0.34–0.54) · Early repair harmful: OR 5.17 (3.97–6.73) · Early repair harmful: OR 3.25 (1.18–8.92) · MA of 10 studies (incl. the Blakely RCT) · 4,253 preterm infants
EUPSA Q4 pooling, 2022 (full text) · Early 18.1% vs late 11.3% (OR 1.42, NS) — opposite direction, non-significant · 5.1% vs 3.3% (OR 4.90) — same direction as Hashmi · 5.7% early vs 1.8% late (OR 3.52, p=0.01) — same direction as Hashmi · MA of 7 retrospective cohorts · 2,024 preterm infants
Why they differ
In recurrence and respiratory complications the two sources agree completely (early repair is worse). The only disagreement is the direction of incarceration: the EUPSA pooling comes from raw retrospective cohorts — and 'early' repair in it was often in smaller, more fragile infants placed on a different pathway (confounding by indication) — while the newer, larger Hashmi pooling includes the randomised trial and adjusted estimates and finds early repair protective against incarceration, as expected mechanically (a repaired hernia does not incarcerate).
Adopted
No single timing figure — the full balance is published: repair before discharge protects against incarceration (OR 0.43, Hashmi) at the price of higher respiratory complications and recurrence (both sources agree), and the EUPSA recommendation (Grade B: delaying until after discharge *may* be beneficial) is the adopted guideline framework for the individual decision.
Justification
When directions conflict on one outcome while agreeing on the rest, the newest, largest and most comprehensively designed source (Hashmi) is adopted at the point of disagreement, and the guideline framework is kept for the decision — averaging the two ratios or choosing the one that suits the narrative is strictly forbidden. [Note 2026-11-08: the later adjudication below changed the absolute figures standing on the card; the delay framing remains as it is.] Later adjudication — 2026-11-08 (live UpToDate check + Tamer's adoption): the UpToDate topic 'Inguinal hernia in children' was opened (topic last updated: Mar 19, 2025; literature review to Oct 2026): it recommends deferring repair of hospitalised preterm infants until after discharge, at about 55 weeks postmenstrual age (Grade 2B) — confirming the delay framing adopted here — and presents the figures of a randomised trial in 122 preterm infants (early repair before NICU discharge vs late at 55 weeks): incarceration 3.5% early vs 12.3% late · post-operative apnoea 15.8% vs 4.6% · bronchopulmonary dysplasia 9.6% vs 1.5% · prolonged hospital stay 11% vs 2%. The trial's incarceration direction agrees with Hashmi and opposes the EUPSA Q4 pooling absolutes in the table above (18.1% early vs 11.3% late). Tamer's decision (2026-11-08): the EUPSA absolutes on the card are replaced by the randomised trial's absolutes as the standing absolute figures; the delay framing (EUPSA Grade B) remains a framework for the decision, not a source of figures; and the EUPSA absolutes remain in dispute table D5 above as documented history tagged as replaced, and do not appear on the cards. The odds ratios from Hashmi are unchanged; and recurrence OR 3.25 was not addressed by the UpToDate topic, so it remains from Hashmi as it is.